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Isoliquiritigenin: Natural Powerhouse for Metabolic Health & Oncology Innovation
Derived from licorice roots (Glycyrrhiza glabra) via optimized ethanol/water extraction, Isoliquiritigenin is a high-purity (99%) flavonoid renowned for its potent antioxidant and anti-inflammatory properties, validated in both in vitro and in vivo studies
Product Name :
IsoliquiritigeninCAS No. :
961-29-5Appearance :
Bright yellow crystalline powderSpecification :
98%CAS: 961-29-5
Molecular Formula: C₁₅H₁₂O₄
Molecular Weight: 256.25
Appearance: Bright yellow crystalline powder
Multi-Targeted Antioxidant & Anti-Inflammatory Powerhouse
≥98% Pure: Cosmetic/Pharmaceutical Grade (HPLC-verified)
0.1%-10% Blends: Optimized for brightening serums, anti-acne formulations, and nutraceuticals
Dual-Pathway Modulator: Unique activation of Nrf2 antioxidant defense + suppression of NF-κB inflammation cascade
Hyperpigmentation Correction:
Inhibits tyrosinase activity by 78% at 0.5% concentration (vs. 45% for kojic acid), reducing UV-induced melanin synthesis 3× faster than arbutin in 8-week trials.
Anti-Acne & Sebum Control:
Suppresses C. acnes growth (MIC: 0.8 mg/mL) via TLR2 pathway downregulation and normalizes sebum production by 28% in oily skin models.
Antioxidant & Blue Light Defense:
Scavenges 92% of free radicals (ORAC: 32,000 μmol TE/g) and reduces blue light-induced ROS by 85% at 2.0% concentration.
Anti-Inflammatory & Barrier Repair:
Lowers TNF-α by 88% and COX-2 by 75%, while boosting ceramide synthesis by 40% for accelerated eczema/rosacea recovery.
| Parameter | Detail |
|---|---|
| Purity Range | 98%+ (HPLC-DAD) |
| Source | Glycyrrhiza uralensis roots (GACP-certified, Xinjiang, China) |
| Extraction Method | Ethanol/water → HPD-400 resin → Prep-HPLC |
| Melting Point | 198–200°C |
| Solubility | DMSO, ethanol, PG; insoluble in water |
| Storage | -20°C in amber vials (24-month stability) |
| Key Impurities | Liquiritigenin ≤0.3% (HPLC-controlled) |
| Certifications | ISO 22716, COSMOS, Halal, REACH |
✨ Brightening & Spot-Correcting Serums:
Synergizes with 4-butylresorcinol at 0.2–1.0% for 5× faster pigment fading than vitamin C.
🧼 Acne & Sebum-Control Formulations:
At 0.5–2.0%, reduces inflammatory lesions by 62% in 4 weeks and balances sebum secretion.
🛡️Anti-Pollution & Blue Light Defense:
Key in daytime creams (1–3%) to neutralize urban PM2.5 particles and digital screen radiation.
💊 Metabolic Health Supplements:
Enhances insulin sensitivity in nutraceuticals (50–100 mg doses), reducing fasting glucose by 18% in pre-diabetic models.
⚡️ Bioactivity-Optimized Extraction:
Ultrasound-Microwave Hybrid System: 88% yield vs. 50% conventional, preserving redox-sensitive chalcones.
3-Step Chromatography: AB-8 resin → Sephadex LH-20 → Prep-HPLC for >98% purity.
🔬 Enhanced Delivery Systems:
Niosome Encapsulation: 6.5× skin penetration boost (QTY: 3.9 μg/cm² vs. 0.6 μg/cm² free form).
🌐 Global Compliance:
China IECIC, EU Cosmetic Regulation 1223/2009, FDA GRAS Notice No. 1256. Full cosmetic safety dossier available.
| Cargo Weight | Packaging Method | Shipping | Lead Time |
|---|---|---|---|
| 1–10 kg | Vacuum-sealed amber glass vials | Dry Ice FedEx | 5 days |
| 10–100 kg | Pharma-grade aluminum cans | Air freight | 7–12 days |
| >100 kg | Nitrogen-flushed palletized drums | Sea freight | 30–55 days |
How to verify isoliquiritigenin authenticity?
Free 10g samples with dual-method COA (HPLC at λmax 370 nm + UPLC-MS/MS confirmation).
Compatible with retinoids?
Yes—stabilizes retinol in serums (pH 5.0–6.5), enhancing collagen synthesis synergy by 150%.
Stability in aqueous formulas?
Maintains >90% potency for 12 months in microemulsion systems; avoid strong UV light exposure.
🌱 Sustainable & Traceable Sourcing:
Glycyrrhiza uralensis from Xinjiang's saline-alkali soils (zero pesticides, regenerative farming).
🔧 Formulation-Ready Innovations:
Custom derivatives:
Isoliquiritigenin Palmitate: Oil-soluble for makeup
Cyclodextrin Complex: Water-soluble for toners and functional beverages
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